The Mercedes-Benz CLK-Class is a mid-size luxury rear-wheel drive coupe and is the coupe version of the C-Class model on which it is based. Major models include the CLK350, CLK550, and CLK63 AMG. The CLK63 AMG's 481 bhp V8 engine is the most powerful. Both generations of the CLK-Class utilize the Mercedes-Benz W208 chassis. There is also a convertible version of the CLK.

The CLK coupe was redesigned for 2003, with the cabriolet following in 2004. The current generation of the CLK-Class is 2.4 inches (61 mm) longer, 0.7 inches (18 mm) wider and 1.1 inch (28 mm) higher than its predecessor.

• The CLK320 features a 3.2 L, 18-valve single overhead cam (SOHC) V6 engine and a five-speed automatic transmission. The base price is US$46,000 for the coupe and US$53,600 for the cabriolet. The CLK320 was replaced by the CLK350 for 2006.
• The CLK350 features a 3.5 L, 24-valve dual overhead cam (DOHC) V6 engine and a seven-speed automatic transmission. The base price is US$45,750 for the coupe and US$53,700 for the cabriolet.
• The CLK500 features a 5.0 L, 24-valve SOHC V8 engine and a seven-speed automatic transmission. The base price is US$54,600 for the coupe and US$62,200 for the cabriolet. The CLK500 was replaced by the CLK550 for 2007.
• The CLK550 features a 5.5L 32-valve V-8 engine and a seven-speed automatic transmission. The base price is US$55,675 for the coupe.
• The CLK55 AMG features a 5.4 L, 24-valve SOHC V8 engine and a 5-speed automatic transmission. The base price is US$69,900 for the coupe and US$82,000 for the cabriolet. The CLK55 AMG coupe was dropped in North America after the 2005 model year, though the cabriolet is still offered. The CLK55 was replaced by the CLK63 for 2007.
• The CLK63 AMG features a 6.2L V8 with a seven-speed automatic transmission. Available in both Coupe and Cabriolet, the CLK63 boasts 481 hp (354 kW) and 465 lb-ft (630 newton m) of torque. Compared to its predecessor the CLK63 has 31% more power and 23% more torque. The CLK63 is currently being used as the safety car in Formula One. It accelerates from 0-60 mph in 4.3 seconds.

In Europe there was also the CLK 200 K (1.8 R4), CLK 220 CDI (2.1 R4 diesel), CLK 240 (2.6 V6), CLK 270 CDI (2.7 R5 diesel), CLK 280 (3.0 V6), CLK 320 CDI (3.0 V6 diesel); (all standard with 6-speed manual transmission, automatic transmission is optional)

Each model seats four and includes an all-leather interior with burl walnut trim. While the CLK320 and CLK500 come with 17 inch (432 mm) alloy wheels, the CLK55 AMG sports 18 inch (457 mm) wheels. The cabriolets have a remote-operated automatic soft-top and sensor-controlled roll bars. Since 2000, all come standard with a Tele Aid emergency assistance system, automatic dual-zone air conditioning, 10-way power front seats and rain-sensing windshield wipers. Seven-channel digital surround sound comes standard. A Keyless Go system, navigation system, Parktronic system, and bi-xenon HID headlamps are all available as options. All models come with four side airbags.